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Interestingly, loss of positive charge through replacement of the three arginine residues, either individually or in combination (R315A, R319A, and R432A), seems to disrupt the coupling between substrate binding and ATP hydrolysis, leading to a futile state in which the protein wastefully hydrolyzes ATP without normal conformational switching
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Cisplatin otoprotection using transtympanic L-N-acetylcysteine: A pilot randomized study in head and neck cancer patients
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