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In a normal dose of 1 gram of acetaminophen four times a day, one-third of patients may have an increase in their liver function tests to three times the normal value.[36] However, it is unclear as to whether this leads to liver failure.[37] Since paracetamol is often included in combination with other drugs, it is important to include all sources of paracetamol when checking a person's dose for toxicity
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Moreover, the complexity of tumor microenvironments and inter-patient variability can affect the performance of NDDS, underscoring the need for more precise, adaptable, and intelligent delivery strategies (Patra et al., 2018)
