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Conclusions and Future Perspectives The GABA pathway (Figure 5) can be roughly divided into two main stages—the metabolic stage, also known as “GABA shunt” [202], involving glutamate and GABA synthesis, as well as GABA catabolism, and the signaling stage, involving GABA traffic, release, interaction with the receptors, and reuptake by GATs
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In clinical patients with non-cancer pain, the incidence of opioid-induced constipation ranges from 40% to 80% 4,5
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