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Dosing paradigms, route of administration, and exposure considerations Published in vivo experiments commonly use intraperitoneal (i.p.) administration at 50 mg/kg twice daily for 12–28 days in adult male C57BL/6J or ob/ob mice, with cohorts kept at thermoneutrality and studied by indirect calorimetry (CLAMS) and body-composition analyses
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doi: 10.1191/096120301680416940
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