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In the presence of differentiation stimuli, abnormal protein folding in the ER activates the unfolded protein response (UPR) signaling, which can be alleviated by global translational attenuation, induction of molecular chaperones, misfolded protein degradation by endoplasmic reticulum-associated degradation (ERAD), and apoptosis (63)
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Vitamin D deficiency, which is prevalent in global south when combined with these disparities, aggravate oral health issues, for its critical role in bone metabolism and immune function