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Further In vitro signal transduction studies showed that, in Colo320wt cells but not in Colo320 cells lacking CCK2R or expressing loss-of-function CCK2R mutant, gastrin stimulates apoptosis, induces MAPK/ERK/AP-1 cascade, and suppresses the activity of NF-κB, indicating CCK2R mediates gastrin-induced apoptosis (158)
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