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The samples were centrifuged by 5 min, at 4 °C, using a speed 12 000 rpm

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Size:600 ct. (120 servings)

Upon activation, mast cells rapidly release pruritogenic mediators such as histamine, prostaglandin D 2 (PGD 2 ), tryptase, and β-hexosaminidase (Poto et al., 2022), which collectively stimulate C-type sensory nerve fibers and trigger neuroimmune amplification (Siiskonen and Harvima, 2019)

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