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however, their safety profile regarding potential liver toxicity and progesterone receptor-associated endometrial changes (PAEC) in endometriotic foci has not been proven with sufficient evidence

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Preclínica · Sci Rep · PubMed · 2021 Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition in obese mice Ratones obesos por dieta, con inhibidor de NNMT y sustitución a dieta magra La combinación aceleró la pérdida de peso y de grasa frente a la dieta sola, redujo el peso del adiposo epididimal y del hígado, y normalizó composición corporal y adiposidad hepática a los valores de controles magros de la misma edad