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Downregulation of the NFR2 gene has been shown to increase retinal degeneration and lead to the development of an AMD-like phenotype with dysregulated autophagy, thus indicating a link between inflammation and oxidative stress [228]
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A Phase 2b randomized controlled trial in celiac disease patients demonstrated larazotide 0.5mg three times daily significantly reduced gastrointestinal symptom scores and celiac disease patient-reported outcome measures versus placebo, despite patients maintaining a gluten-free diet
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