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When this control is changed by oxidative or electrophilic signals, Nrf2 can accumulate and increase the expression of antioxidant-response genes, including those involved in GSH synthesis
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Difference between PD patients and healthy controls include a reduction in bacterial community that produce butyrate such as Faecalibacterium prausnitzii , and a rise in mucin-degrading species such as Akkermansia muciniphila (42)