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At present, many evidences indicate that AMPK activation is a master node of anti-tumor effects of metformin [3] , [16] , [23] , therefore, LKB1 −/− cancer cells are more resistant to metformin-induced cytotoxicity in the in vitro culture system [22] , [34]
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The Shift to "Rest and Digest" Many Canadians live in a state of chronic "fight or flight," driven by caffeine, stress, and high-pressure schedules