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To support this finding, a study conducted with heterogeneous collagen hydrolysates (From porcine: Mobiforte ® , Astrid Twardy GmbH, Unterföhring, Germany and fish: Peptan ® F 5000 and Peptan ® F 2000 from Rousselot SAS, Puteaux, France) showed a negative impact on modulating collagen biosynthesis in human knee cartilage explants, and there was also evidence of elevated aggrecanases (ADMATS4 and ADMATS5), IL-6, MMP-1, -3, and -13 levels [144]
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