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More explanatory evidence in the future will require the simultaneous reporting of metabolites/metabolic ratios and cellular phenotypic outputs within a unified network framework, together with the integration of multi-model data stratified by tissue and disease stage, so as to move from “pathway-level associations” toward definable metabolic nodes and translatable therapeutic windows
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and S.J.), the Helmut Horten Foundation (to S.J.), the Betty & David Koetser Foundation (to S.J.), a Forschungskredit of the University of Zurich (to A.D.-L.) and the Zurich Neuroscience Center (to S.J.)