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Glutathione levels are depleted by aging, chronic oxidative stress, excessive alcohol consumption, smoking, poor nutrition, chronic diseases, infections, environmental toxins, and certain medications such as high-dose acetaminophen, which increases glutathione use during detoxification
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25 - 29 The first-in-class retainagogue, tenapanor, was approved in 2019 and was launched in the United States in 2022