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The levels of the intermediates malic acid and isocitrate increase and promote the activity of their corresponding mitochondrial enzymes, leading to NADPH generation (44)
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Mitochondrial and lysosomal dysfunction, dysregulated iron metabolism, and accumulation of ROS are considered to be pivotal elements in the pathogenesis of PD, ultimately leading to neuronal degeneration and death (Matak et al., 2016
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