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This novel mechanism has delivered unprecedented weight-loss results in clinical trials: 24.2% body weight reduction at 48 weeks in the peer-reviewed Phase 2 trial (Jastreboff et al., NEJM 2023), and preliminary topline Phase 3 data from TRIUMPH-4 reporting 28.7% at 68 weeks in patients with obesity and knee osteoarthritis (pending full peer-reviewed publication) — making it one of the most potent obesity treatments ever studied
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