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Other diluent volumes scale linearly: 3 mL gives roughly 3.33 mg/mL, 5 mL gives 2 mg/mL

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Methods Animals Animal experiments were performed with adherence to all national and local guidelines and regulations, the Guide for the Care and Use of Laboratory Animals 25 , and the ARRIVE guidelines, and with the approval of the Institutional Animal Care and Use Committee at The University of Texas Medical Branch (UTMB)