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Protein targeted for degradation is tagged with a highly conserved 8 1-( N , N -dimethylamino)diazen-1-ium-1,2-diolate) PD Parkinson's disease PDI protein disulfide isomerase PDK phosphoinosityl-dependent kinase PERK pancreatic ER kinase PI3K phosphoinositide 3 kinase PKA protein kinase A PKC protein kinase C PP2A protein phosphatase 2A Prx peroxiredoxin PTEN phosphatase and tensin homolog deleted from chromosome 10 PTP protein tyrosine phosphatase RNS reactive nitrogen species ROS reactive oxygen species RyR ryanodine receptor SDH succinate dehydrogenase SERCA sarcoplasmic endoplasmic reticulum calcium ATPase SHP Src-homology protein tyrosine phospphatase SP senile plaques TNFα tumor necrosis factor alpha TRAF2 TNF receptor-associated factor 2 UPR unfolded protein response Footnotes Reviewing Editors: Adam Benham, Isabella Dalle-Donne, Christopher H