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Based on the observation that Keap1 functions as a homodimer, the heterozygous missense mutation generates three types of Keap1 dimers, i.e., wild-type homodimer, wild-type-mutant heterodimer, and mutant homodimer at a ratio of 1:2:1
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Glutathione S-transferase isoenzymes and glutathione in renal cell carcinoma and… [PMID: 7659181] Laboratory literature summary: Glutathione S-transferase isoenzymes and glutathione in renal cell carcinoma and kidney tissue