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The notion that oxidative damage likely influences konzo susceptibility has been long theorized since this disease is associated with the consumption of cyanogenic compounds that are well known to increase radicals either through direct inhibition of mitochondrial respiration or through toxicity of the downstream metabolites of cyanide 12,18

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Metabolites were resolved across a 2.1 × 150 mm, 1.7 µm Kinetex C18 column (Phenomenex) using a 5-min, reverse-phase gradient from a previously described method 19

2 capsules 1 to 2 times daily between meals