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Flohe’s objection points out that the rate constants for the spontaneous reactions of inter-conversion of thiol disulfides are negligibly small, with respect to those necessary to explain biological processes, and therefore the intervention of the enzymatic systems is of a crucial importance in determining the behavior of a biological system

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When the bait ligand was aML5-FLAG, only a single Met fragment was isolated (Supplementary Table 4), indicating that it selectively bound to Met