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The pivotal trial supporting its 2010 FDA approval enrolled 816 HIV-infected adults with clinically defined lipodystrophy, and Phase 3 data documented visceral fat reductions of roughly 15-18% over 26 weeks of treatment a result robust enough to clear FDA review for a defined medical indication
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Emerging Research Directions: What the 2026 Literature Reveals Since 2024, several research groups have expanded beyond rodent models into larger-animal and ex vivo human tissue studies
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